Walter L, Marynen P, Szpirer J, Levan G, Günther E
Division of Immunogenetics, University of Göttingen, Germany.
Genomics. 1995 Jul 20;28(2):301-4. doi: 10.1006/geno.1995.1145.
A novel gene, TEGT (testis enhanced gene transcript), has been identified in humans. It does not belong to any known gene family of vertebrates. The deduced amino acid sequence of the gene and a bacterial protein of unknown function show low but significant homology and very similar hydrophobicity profiles. Two different transcripts of TEGT occur, which are due to alternative usage of two polyadenylation sites. The presence of a nuclear targeting motif indicates that the gene product might localize to the nucleus. The TEGT gene maps to human chromosome 12q12-q13 and belongs to a syntenic group, which is conserved in human, mouse, and rat.
在人类中已鉴定出一种新基因，即TEGT（睾丸增强基因转录本）。它不属于任何已知的脊椎动物基因家族。该基因推导的氨基酸序列与一种功能未知的细菌蛋白显示出低但显著的同源性以及非常相似的疏水性图谱。TEGT存在两种不同的转录本，这是由于两个聚腺苷酸化位点的选择性使用所致。核靶向基序的存在表明该基因产物可能定位于细胞核。TEGT基因定位于人类染色体12q12 - q13，属于一个在人类、小鼠和大鼠中保守的同线群。
