Redondo J M, Hernandez-Munain C, Krangel M S
Centro de Biología Molecular, Facultad de Ciencias CSIC-UAM, Madrid, Spain.
Immunobiology. 1995 Jul;193(2-4):288-92. doi: 10.1016/s0171-2985(11)80557-7.
T cell receptor delta gene expression is regulated by a T cell-specific transcriptional enhancer located within the J delta 3-C delta intron. An essential element of the enhancer was localized to a small 30 bp segment denoted delta E3. Two specific factors, CBF/PEBP2 and c-Myb, bind to adjacent sites within delta E3 and cooperate functionally to mediate transcriptional activation. These factors are likely to play essential roles in the developmental activation of the TCR delta gene in vivo.
T细胞受体δ基因的表达受位于Jδ3-Cδ内含子内的一个T细胞特异性转录增强子调控。该增强子的一个关键元件定位于一个30 bp的小片段，称为δE3。两个特异性因子，CBF/PEBP2和c-Myb，结合于δE3内的相邻位点，并在功能上协同介导转录激活。这些因子可能在体内TCRδ基因的发育激活中发挥关键作用。
