Stratowa C, Audette M
Ernst Boehringer Institut, Bender & Co, Vienna, Austria.
Immunobiology. 1995 Jul;193(2-4):293-304. doi: 10.1016/S0171-2985(11)80558-9.
Human intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein that functions as a ligand for lymphocyte function-associated antigen-1, plays an important role in mediating cell-cell interactions in inflammatory reactions. It is induced by proinflammatory cytokines such as interleukin-1, tumor necrosis factor-alpha or interferon-gamma, as well as by phorbol esters, retinoic acid and lipopolysaccharide. Furthermore, ICAM-1 is upregulated by interleukin-6, which suggests that it belongs to the family of acute phase response genes. Investigation of the 5'-regulatory region of the human ICAM-1 gene revealed sequence motifs for a variety of transcription factors implicated in transcriptional regulation. This review summarizes the current knowledge of the transcriptional regulation of the human ICAM-1 gene.
人细胞间黏附分子-1（ICAM-1）是一种跨膜糖蛋白，作为淋巴细胞功能相关抗原-1的配体发挥作用，在介导炎症反应中的细胞间相互作用中起重要作用。它由促炎细胞因子如白细胞介素-1、肿瘤坏死因子-α或干扰素-γ诱导产生，也可由佛波酯、视黄酸和脂多糖诱导产生。此外，ICAM-1可被白细胞介素-6上调，这表明它属于急性期反应基因家族。对人ICAM-1基因5'调控区的研究揭示了多种参与转录调控的转录因子的序列基序。本综述总结了目前关于人ICAM-1基因转录调控的知识。
