Tsimoyiannis E C, Siakas P, Moutesidou K J, Karayianni M, Kontoyiannis D S, Gossios K J
Department of Surgery, G. Hatzikosta General Hospital, Ioannina, Greece.
Int Surg. 1995 Apr-Jun;80(2):131-3.
Primary treatment of liver hydatidosis is surgical, but the recurrence rate is about 10%. To minimize the risk of recurrence, 67 consecutive patients with liver hydatidosis were prospectively treated by mebendazole or albendazole for 5 days before surgery. During the operation the viability of the protoscoleces was assessed. Seventeen patients who had viable protoscoleces at the time of the operation received the same benzimidazole one extra month postoperatively, while the remaining 50 patients who had dead protoscoleces didn't receive postoperative therapy. None of the patients developed recurrence of the disease after a follow-up period of 15-67 months (average 41 months). These results suggest that a 5-day preoperative benzimidazole therapy either combined or not with a monthly postoperative course according to the viability of the protoscoleces at the time of operation, may erase the risk of recurrence after surgical treatment of the liver hydatidosis.
肝包虫病的主要治疗方法是手术，但复发率约为10%。为了将复发风险降至最低，我前瞻性地对67例肝包虫病患者在手术前给予甲苯咪唑或阿苯达唑治疗5天。术中评估原头节的活力。17例术中原头节存活的患者在术后额外接受了1个月相同的苯并咪唑治疗，而其余50例原头节已死亡的患者未接受术后治疗。在15 - 67个月（平均41个月）的随访期后，所有患者均未出现疾病复发。这些结果表明，术前5天的苯并咪唑治疗，无论是否根据术中原头节的活力联合术后每月疗程，均可消除肝包虫病手术治疗后的复发风险。
