McCaig D J, Stewart D, Harvey Y, Downie G, Scott C J
School of Pharmacy, Robert Gordon University, Schoolhill, Aberdeen.
Health Bull (Edinb). 1995 Nov;53(6):359-64.
The aim of the study was to compare the antibiotic treatment actually received by elderly, hospitalised patients with urinary tract infection (UTI) with 'optimal' therapy (as gauged by compliance with antibiotic policy, infecting organism, sensitivity data, patient renal function and cost). UTI was more common in females and in catheterised patients and E.Coli was the commonest pathogen. Trimethoprim and co-amoxiclav were the drugs used most frequently for either empirical or sensitivity data-based treatment. In 96% of infections a drug with appropriate action was administered. Often, however, treatment could have been optimised by substituting a cheaper suitable antibiotic, by standardising duration of therapy and ensuring that doses were adjusted for renal impairment. Savings from the use of 'optimal' therapy were estimated at 17%. There is clearly considerable scope for positive input from the clinical pharmacist in this area.
该研究的目的是将老年住院尿路感染（UTI）患者实际接受的抗生素治疗与“最佳”治疗（根据抗生素政策的依从性、感染病原体、敏感性数据、患者肾功能和成本来衡量）进行比较。UTI在女性和留置导尿管的患者中更为常见，大肠杆菌是最常见的病原体。甲氧苄啶和阿莫西林克拉维酸钾是最常用于经验性治疗或基于敏感性数据治疗的药物。在96%的感染中，使用了具有适当作用的药物。然而，通常可以通过改用更便宜的合适抗生素、规范治疗疗程以及确保根据肾功能损害调整剂量来优化治疗。使用“最佳”治疗估计可节省17%。临床药剂师在这一领域显然有很大的积极作用空间。
