Bennegård-Edén B, Hahlin M, Kindahl H
Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, University of Göteborg, Sweden.
Hum Reprod. 1995 Sep;10(9):2320-4. doi: 10.1093/oxfordjournals.humrep.a136293.
The effect of a single injection of oxytocin into the corpus luteum, with or without pretreatment with a prostaglandin synthetase inhibitor, was studied in order to investigate possible local interactions between prostaglandin (PG)F2 alpha and oxytocin in the regulation of the human corpus luteum. Oxytocin (4 IU) was injected through the abdominal wall into the corpus luteum in women undergoing laparoscopy for legal sterilization. In the control cases, saline was injected into the corpus luteum, or oxytocin was injected into the contralateral ovary. Oxytocin injected into the corpus luteum caused a fall in serum progesterone and shortened the luteal phase. These effects were not seen following injection of saline into the corpus luteum, or following injection of oxytocin into the contralateral ovary. After the injection of oxytocin into the corpus luteum a rise in 15-keto-dihydro-PGF2 alpha, a PGF2 alpha metabolite, was seen. The changes in serum progesterone caused by injection of oxytocin into the corpus luteum could be prevented if a PG synthetase inhibitor was given before the injection. These findings suggest that local interaction between oxytocin and PGF2 alpha plays a role in the regulation of the human corpus luteum.
为了研究前列腺素（PG）F2α和催产素在人类黄体调节中可能存在的局部相互作用，研究人员对黄体单次注射催产素（无论是否预先使用前列腺素合成酶抑制剂）的效果进行了研究。在因合法绝育而接受腹腔镜检查的女性中，通过腹壁将催产素（4国际单位）注入黄体。在对照病例中，将生理盐水注入黄体，或将催产素注入对侧卵巢。向黄体注射催产素会导致血清孕酮水平下降，并缩短黄体期。向黄体注射生理盐水后，或向对侧卵巢注射催产素后，均未观察到这些效应。向黄体注射催产素后，可见PGF2α代谢产物15-酮-二氢-PGF2α升高。如果在注射催产素前给予PG合成酶抑制剂，则可防止因向黄体注射催产素而引起的血清孕酮变化。这些发现表明，催产素和PGF2α之间的局部相互作用在人类黄体的调节中起作用。
