Dickey R P, Hower J F
Fertility Institute of New Orleans, Louisiana, USA.
Hum Reprod. 1995 Sep;10(9):2448-52. doi: 10.1093/oxfordjournals.humrep.a136317.
Uterine blood flow volume has been thought to increase in a linear fashion throughout pregnancy, but previous studies in early pregnancy may have not been performed often enough or in sufficient numbers of patients. We measured uterine artery blood flow volume, average velocity, vessel cross-sectional area, resistance index, and spiral artery resistance index with Doppler ultrasound at 1-3 week intervals from gestational (post-menstrual) weeks 5-6 to week 16 in 44 normal, spontaneous, single pregnancies. Uterine artery blood flow volume and velocity increased gradually until the end of week 9, and then rapidly from weeks 10-16. Uterine artery vessel size increased linearly. The uterine artery resistance index was the inverse of volume and velocity, in contrast to the spiral artery resistance index, which decreased linearly. These findings indicate that early pregnancy changes in uterine and spiral artery blood flow occur by different mechanisms, and that when investigating uterine blood flow in early pregnancy, studies need to begin by week 6 and need to be performed at least biweekly.
子宫血流量在整个孕期一直被认为是以线性方式增加的，但先前关于早孕的研究可能没有足够频繁地进行，或者纳入的患者数量不足。我们对44例正常、自然单胎妊娠的孕妇，在妊娠（月经后）第5 - 6周开始至第16周期间，每隔1 - 3周用多普勒超声测量子宫动脉血流量、平均速度、血管横截面积、阻力指数和螺旋动脉阻力指数。子宫动脉血流量和速度在第9周结束前逐渐增加，然后在第10 - 16周迅速增加。子宫动脉血管大小呈线性增加。子宫动脉阻力指数与血流量和速度呈反比，而螺旋动脉阻力指数则呈线性下降。这些发现表明，早孕时子宫和螺旋动脉血流的变化是由不同机制引起的，并且在研究早孕时子宫血流时，研究需要在第6周开始，并且至少每两周进行一次。
