Ralston M E, Pearigen P D, Ponaman M L, Erickson L C
Department of Pediatrics, Naval Medical Center, San Diego, California 92134-5000, USA.
J Emerg Med. 1995 Sep-Oct;13(5):657-9. doi: 10.1016/0736-4679(95)00073-j.
Aspirin overdose may result in acid-base disturbances, electrolyte abnormalities, pulmonary edema, chemical hepatitis, seizures, and mental status alteration, but myocardial depression has not been reported following aspirin overdose in children. In addition to these more typical features, the 13-month-old boy reported here developed clinical, radiographic, and echocardiographic evidence of myocardial impairment with pulmonary edema and moderately severe global left ventricular dysfunction (estimated shortening fraction of 23%). Complete resolution of the myocardial dysfunction was demonstrated on follow-up echocardiography as the child recovered from the aspirin intoxication. This case suggests that myocardial dysfunction can occur as a result of toxic aspirin ingestion, and that it may contribute to salicylate-induced pulmonary edema.
阿司匹林过量可能导致酸碱平衡紊乱、电解质异常、肺水肿、化学性肝炎、癫痫发作和精神状态改变，但儿童阿司匹林过量后尚未有心肌抑制的报道。除了这些更典型的特征外，本文报道的这名13个月大的男孩出现了心肌损伤的临床、影像学和超声心动图证据，伴有肺水肿和中度严重的全心左心室功能障碍（估计缩短分数为23%）。随着患儿从阿司匹林中毒中恢复，后续超声心动图显示心肌功能障碍完全消退。该病例表明，摄入有毒剂量的阿司匹林可能导致心肌功能障碍，并且这可能是水杨酸盐诱导的肺水肿的原因之一。
