Imai Y, Akiyama N, Hanazono Y, Inamori K, Mitani K, Hirai H, Nagai R, Yazaki Y
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo.
Rinsho Ketsueki. 1995 Oct;36(10):1233-6.
Here we report a 65-year-old male patient with idiopathic myelofibrosis (IMF) accompanied with acromegaly. He was admitted because of anemia and splenomegaly. No favorable effects were observed when hydroyurea was administered. However, his symptoms were successfully treated by administration of vincristine and prednisolone (VP therapy), which is usually applied for choronic myelogenous leukemia in the accelerated phase. Therefore, VP therapy might be one possible for IMF. Since there have been several reports suggesting the possible association of hematological malignancies with acromegaly, we speculate that acromegaly was implicated in the initiation or progression of IMF in this case.
在此，我们报告一例65岁男性特发性骨髓纤维化（IMF）合并肢端肥大症患者。他因贫血和脾肿大入院。给予羟基脲治疗后未观察到明显疗效。然而，通过给予长春新碱和泼尼松（VP疗法）成功治疗了他的症状，VP疗法通常用于慢性髓性白血病加速期。因此，VP疗法可能是IMF的一种治疗选择。由于已有多篇报道提示血液系统恶性肿瘤与肢端肥大症可能存在关联，我们推测在该病例中肢端肥大症与IMF的发生或进展有关。
