Tsuruo T
Institute of Molecular and Cellular Biosciences, University of Tokyo.
Nihon Rinsho. 1995 Oct;53(10):2604-11.
Resistance of tumors to a variety of chemotherapeutic agents presents a major problem in cancer treatment. The gene responsible for multidrug resistance, termed mdr1, encodes a membrane glycoprotein (P-glycoprotein) that acts as a pump to transport various cytotoxic agents. The P-glycoprotein has been shown to bind anticancer drugs and several resistance-reversing agents including calcium channel blockers, and to be an ATPase. The P-glycoprotein was found to function in blood-brain barrier. The implication of the P-glycoprotein in relation to therapy is discussed.
肿瘤对多种化疗药物产生耐药性是癌症治疗中的一个主要问题。负责多药耐药的基因，称为mdr1，编码一种膜糖蛋白（P-糖蛋白），它作为一种泵来转运各种细胞毒性药物。已证明P-糖蛋白能结合抗癌药物和几种耐药逆转剂，包括钙通道阻滞剂，并且是一种ATP酶。发现P-糖蛋白在血脑屏障中发挥作用。本文讨论了P-糖蛋白与治疗的关系。
