Reich T
J Am Geriatr Soc. 1977 May;25(5):202-5. doi: 10.1111/j.1532-5415.1977.tb00300.x.
Thirty-nine patients with arterial insufficiency of the lower limbs were treated with cyclandelate or placebo in a double-blind cross-over study, to evaluate the effect of this drug on symptomatic and physiologic indicators of circulatory status. The following measurements were used: skin temperature of the big toe and dorsum of the foot; blood flow in the calf at rest and after exercise on a foot ergometer to the point of claudication; walking distance to the development of claudication; exercise tolerance on a foot ergometer; and reflex vasoconstriction on the skin of the toe in response to cooling of the upper extremities. During treatment with cyclandelate, significant improvement occurred in each of these measures of circulatory efficiency.
在一项双盲交叉研究中，39名下肢动脉供血不足患者接受了环扁桃酯或安慰剂治疗，以评估该药物对循环状态的症状和生理指标的影响。采用了以下测量方法：大脚趾和足背的皮肤温度；休息时以及在足部测力计上运动至出现跛行后小腿的血流量；出现跛行时的行走距离；在足部测力计上的运动耐力；以及上肢冷却时脚趾皮肤的反射性血管收缩。在使用环扁桃酯治疗期间，这些循环效率指标均有显著改善。
