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人类大脑皮层中突触前5-羟色胺自身受体作为5-HT1D受体的亚分类。

Subclassification of presynaptic 5-HT autoreceptors in the human cerebral cortex as 5-HT1D receptors.

作者信息

Fink K, Zentner J, Göthert M

机构信息

Institut für Pharmakologie und Toxikologie, Universität Bonn, Germany.

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1995 Oct;352(4):451-4. doi: 10.1007/BF00172785.

DOI:10.1007/BF00172785
PMID:8532076
Abstract

Human cerebral cortical synaptosomes were used to determine the 5-hydroxytryptamine (5-HT) receptor subtype to which the inhibitory presynaptic 5-HT autoreceptor belongs. The synaptosomes preincubated with [3H]5-HT were superfused and tritium overflow was stimulated by high K+. The K(+)-evoked tritium overflow, which was Ca(2+)-dependent but tetrodotoxin-resistant, was concentration-dependently inhibited by the nonselective 5-HT 1D alpha/1D beta receptor agonist, 5-carboxamidotryptamine. Ketanserin at a concentration which should block the 5-HT 1D alpha but not the 5-HT 1D beta receptor failed to antagonize the inhibitory effect of 5-carboxamidotryptamine. In contrast, the nonselective 5-HT 1D alpha/1D beta receptor antagonist, methiothepin, at a concentration which should block both the 5-HT 1D alpha and the 5-HT 1D beta receptor abolished the effect of 5-carboxamidotryptamine. It is concluded that the presynaptic 5-HT autoreceptor, which has previously been classified as 5-HT 1D, belongs to the 5-HT1D beta subtype.

摘要

使用人脑皮质突触体来确定抑制性突触前5-羟色胺（5-HT）自身受体所属的5-HT受体亚型。将预先与[3H]5-HT共同孵育的突触体进行灌流，并通过高钾离子刺激氚外流。钾离子诱发的氚外流依赖于钙离子但对河豚毒素有抗性，非选择性5-HT 1Dα/1Dβ受体激动剂5-羧酰胺色胺可浓度依赖性地抑制这种外流。酮色林在应能阻断5-HT 1Dα但不阻断5-HT 1Dβ受体的浓度下，未能拮抗5-羧酰胺色胺的抑制作用。相反，非选择性5-HT 1Dα/1Dβ受体拮抗剂美噻吨在应能同时阻断5-HT 1Dα和5-HT 1Dβ受体的浓度下，消除了5-羧酰胺色胺的作用。得出的结论是，先前被归类为5-HT 1D的突触前5-HT自身受体属于5-HT1Dβ亚型。

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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Pharmacological characterisation of [35S]-GTPgammaS binding to Chinese hamster ovary cell membranes stably expressing cloned human 5-HT1D receptor subtypes.[35S]-鸟苷-5'-O-(3-硫代三磷酸)（[35S]-GTPγS）与稳定表达克隆的人5-羟色胺1D（5-HT1D）受体亚型的中国仓鼠卵巢细胞膜结合的药理学特性研究
J Recept Signal Transduct Res. 1995 Jan-Mar;15(1-4):199-211. doi: 10.3109/10799899509045217.
3
Presynaptic 5-HT auto- and heteroreceptors in the human central and peripheral nervous system.
与大鼠新皮层相比，人类去甲肾上腺素能和5-羟色胺能神经元上的突触前阿片受体。
Br J Pharmacol. 2006 Jul;148(6):795-806. doi: 10.1038/sj.bjp.0706782. Epub 2006 Jun 5.
4
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions.位于不同神经元上且参与不同功能的天然人类5-HT1B和5-HT1D受体之间的药理学差异。
Br J Pharmacol. 1999 Feb;126(3):607-12. doi: 10.1038/sj.bjp.0702336.
5
Presynaptic inhibitory serotonin autoreceptors in the human hippocampus.人类海马体中的突触前抑制性5-羟色胺自身受体。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):393-6. doi: 10.1007/BF00171075.
6
Evidence for presynaptic location of inhibitory 5-HT1D beta-like autoreceptors in the guinea-pig brain cortex.豚鼠大脑皮层中抑制性5-HT1Dβ样自身受体突触前定位的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):281-9. doi: 10.1007/BF00168629.
7
Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium.通过人心房中突触前5-HT1Dα受体抑制去甲肾上腺素释放。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):272-80. doi: 10.1007/BF00168628.
人类中枢和外周神经系统中的突触前5-羟色胺自身受体和异源受体。
Behav Brain Res. 1996;73(1-2):89-92. doi: 10.1016/0166-4328(96)00076-9.
4
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J Neurochem. 1993 Mar;60(3):1179-82. doi: 10.1111/j.1471-4159.1993.tb03274.x.
5
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6
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).5-羟色胺（血清素）受体的国际药理学联合会分类
Pharmacol Rev. 1994 Jun;46(2):157-203.
7
Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.大鼠大脑皮层中抑制性突触前5-羟色胺（5-HT）自身受体与5-HT1B结合位点的同一性。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jan;332(1):1-7. doi: 10.1007/BF00633189.
8
Serotonin release in human cerebral cortex and its modulation via serotonin receptors.血清素在人类大脑皮层中的释放及其通过血清素受体的调节。
Brain Res. 1985 Apr 8;331(2):337-41. doi: 10.1016/0006-8993(85)91559-8.
9
Modulation of neurotransmitter release by presynaptic autoreceptors.突触前自身受体对神经递质释放的调节。
Physiol Rev. 1989 Jul;69(3):864-989. doi: 10.1152/physrev.1989.69.3.864.
10
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Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):508-12. doi: 10.1007/BF00169037.