Metabotropic glutamate receptor agonist trans-azetidine-2,4-dicarboxylic acid facilitates maintenance of LTP in the dentate gyrus in vivo.
作者信息
Riedel G, Manahan-Vaughan D, Kozikowski A P, Reymann K G
机构信息
Federal Institute for Neurobiology, Department of Neurophysiology, Magdeburg, Germany.
出版信息
Neuropharmacology. 1995 Aug;34(8):1107-9. doi: 10.1016/0028-3908(95)00110-r.
PMID:8532161
Abstract
We examined the role of metabotropic glutamate receptors by studying the effect of intracerebroventricular infusion of the putative mGluR agonist trans-azetidine-2,4-dicarboxylic acid (tADA) on long-term potentiation (LTP) in the dentate gyrus of freely moving rats. Weak tetanization caused a decremental potentiation which returned to baseline levels within 2 hr. Injections of tADA (20 mM/5 microliters) 30 min prior to weak tetanization prolonged LTP of the field EPSP for at least 24 hr.
摘要
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