Pradella P, Maculotti L, Sesana G
Divisione di Chirurgia Generale Andrea Ponti, Ospedale Ca Granda Niguarda, Milano.
Minerva Chir. 1995 Jul-Aug;50(7-8):637-41.
Fourteen patients affected by primary gastric lymphoma were observed retrospectively to verify the results of surgical and adjuvant chemotherapy. After a 85% preoperative diagnostic specificity, 79% of patients were subjected to surgical therapy by subtotal gastrectomy (93%) and by total gastrectomy (7%), and 64% of patients were subjected to adjuvant chemotherapy in conformity with CHOP and CVP. Classified by the Working formulation, 57% of cases presented a high grade of malignancy, 29% a low grade and 14% an intermediate grade. Classified by Ann Arbor with Mushoff's modification, 43% of patients were assigned to stage IIE1, 36% to stage IE, 14% to stage IIE2 and 7% to stage IIIE. Operative mortality was null. The overall median survival have been of 21 months, while surgical and chemotherapeutical median survival reached 32 months. The 5-year actuarial survival was: 10% (overall), 14% (treated patients), 50% (low grade), 33% (stage IE). With negative influence by istology and staging.
对14例原发性胃淋巴瘤患者进行回顾性观察,以验证手术及辅助化疗的结果。术前诊断特异性为85%,79%的患者接受了手术治疗,其中93%行胃次全切除术,7%行全胃切除术,64%的患者按照CHOP和CVP方案接受辅助化疗。根据工作分类法,57%的病例为高恶性度,29%为低恶性度,14%为中恶性度。根据Ann Arbor分期并采用Mushoff修正法,43%的患者被归为IIE1期,36%为IE期,14%为IIE2期,7%为IIIE期。手术死亡率为零。总体中位生存期为21个月,而手术和化疗后的中位生存期达32个月。5年精算生存率为:总体10%,接受治疗患者14%,低恶性度50%,IE期33%。受组织学和分期的负面影响。