Zharhary D, Gershon H
J Immunol Methods. 1977;15(3):247-53. doi: 10.1016/0022-1759(77)90062-x.
Methods for the synthesis of the mono-, di- and tri-nitro derivatives of epsilon-aminocaproic acid are presented. Special attention is given to the purification procedure, as we have found that methods recommended in the literature do not produce a single product. Evidence is presented which shows that recrystallizing the haptens from hot ethanol produces a by-product which is the ethyl ester of the haptens. Characterization methods and physical properties of the nitro-phenylated derivates of epsilon-aminocaproic acid are summarized.
本文介绍了ε-氨基己酸单硝基、二硝基和三硝基衍生物的合成方法。特别关注了纯化过程，因为我们发现文献中推荐的方法不能得到单一产物。有证据表明，从热乙醇中重结晶半抗原会产生一种副产物，即半抗原的乙酯。总结了ε-氨基己酸硝基苯基化衍生物的表征方法和物理性质。
