Banks W A, Kastin A J
Veterans Affairs Medical Center, New Orleans, LA 70146, USA.
Peptides. 1995;16(6):1157-61. doi: 10.1016/0196-9781(95)00043-j.
Adrenocorticotropin (ACTH)-related compounds, termed melanocortins, produce a large number of effects on the central nervous system (CNS) after their peripheral administration. Some of the CNS effects of ACTH are mediated through the release of glucocorticoids from the adrenal gland, but there are fragments and analogues of ACTH that do not act on the adrenals. This raises the possibility that some blood-borne melanocortins may be acting directly on the brain, which would necessitate their crossing the blood-brain barrier (BBB). We review here the literature showing that melanocortins can affect the BBB in several ways, including an alteration of the permeability of the BBB to other substances.
促肾上腺皮质激素（ACTH）相关化合物，即促黑素，在外周给药后会对中枢神经系统（CNS）产生大量影响。ACTH的一些中枢神经系统作用是通过肾上腺释放糖皮质激素介导的，但也有一些ACTH片段和类似物并不作用于肾上腺。这就增加了一种可能性，即一些经血传播的促黑素可能直接作用于大脑，这就需要它们穿过血脑屏障（BBB）。我们在此回顾相关文献，这些文献表明促黑素可以通过多种方式影响血脑屏障，包括改变血脑屏障对其他物质的通透性。
