Van de Voorde W M, Van Poppel H P, Verbeken E K, Oyen R H, Baert L V, Lauweryns J M
Department of Pathology, University Hospitals, Katholieke Universiteit, Leuven, Belgium.
Mod Pathol. 1995 Aug;8(6):591-8.
We examined retrospectively 107 step-sectioned radical prostatectomy specimens. The index tumor in each specimen was designated a transition zone carcinoma (TZCa) or a peripheral zone carcinoma (PZCa) based on its location. All tumor sections were immunohistochemically stained with chromogranin A (ChrA). A semiquantitative ChrA score (0 to 3) was assessed. ChrA-positive neuroendocrine cells were found in 83% of the index tumors. The ChrA score was significantly related to the Gleason score, the volume of the tumor, and the pathologic stage. Twenty-two percent of the index tumors were designated TZCas; 75% of these demonstrated neuroendocrine differentiation versus 85% of the PZCas. A high ChrA score of > or = 2 was found in 46% of PZCas and in only 33% of TZCas. Capsular transgression, seminal vesicle involvement, positive surgical margins, and lymph node metastasis were seen in the TZCa group in 33%, 17%, 29%, and 4%, respectively versus 58%, 20%, 48%, and 6% in the PZCa group. These findings were associated with a higher mean tumor volume in the TZCa group compared with the PZCa group. The average Gleason score of 4.5 in the TZCa group was significantly (P < 0.0001) lower than the Gleason score 6.2 in the PZCa group. Multicentricity was found in 62% of TZCas and in 49% of PZCas. Eighty-seven percent of the second tumors in the prostates with a primary TZCa were located in the peripheral zone. We conclude that the frequently occurring neuroendocrine cells population enlarges with tumor progression, especially in PZCas.(ABSTRACT TRUNCATED AT 250 WORDS)
我们回顾性研究了107例根治性前列腺切除术的连续切片标本。根据肿瘤位置，将每个标本中的索引肿瘤分为移行区癌（TZCa）或外周区癌（PZCa）。所有肿瘤切片均用嗜铬粒蛋白A（ChrA）进行免疫组化染色。评估半定量ChrA评分（0至3）。在83%的索引肿瘤中发现了ChrA阳性神经内分泌细胞。ChrA评分与Gleason评分、肿瘤体积和病理分期显著相关。22%的索引肿瘤为TZCa；其中75%表现出神经内分泌分化，而PZCa为85%。46%的PZCa中ChrA高评分≥2，而TZCa中仅为33%。TZCa组中包膜侵犯、精囊受累、手术切缘阳性和淋巴结转移分别为33%、17%、29%和4%，而PZCa组分别为58%、20%、48%和6%。这些发现与TZCa组比PZCa组更高的平均肿瘤体积相关。TZCa组平均Gleason评分为4.5，显著低于（P<0.0001）PZCa组的Gleason评分6.2。62%的TZCa和49%的PZCa中发现多中心性。原发性TZCa前列腺中87%的第二个肿瘤位于外周区。我们得出结论，随着肿瘤进展，频繁出现的神经内分泌细胞群体会扩大，尤其是在PZCa中。（摘要截短至250字）
