Skisak C, DiGiovanni J, Conti C J, Slaga T J, Sharma S, Sagartz J W, Walborg E F
Pennzoil Co., Houston, Texas 77252, USA.
Prog Clin Biol Res. 1995;391:439-44.
The induction of sustained epidermal hyperplasia in mouse skin has been shown to be a reliable predictor of tumor promoting activity for chemicals as diverse as phorbol esters, anthralins, n-dodecane and organic peroxides (DiGiovanni, 1992). The results contained herein demonstrate that API 81-07 and API 81-10, petroleum middle distillates that exhibit tumor promoting activity in mouse skin, induce epidermal hyperplasia and ODC activity. Other petroleum middle distillates (odorless light petroleum hydrocarbons, a light vacuum distillate, and a mineral seal oil) were also shown to share these activities. It should be emphasized that the relevance of these observations to human skin remains unresolved; however, the availability of these short-term biomarkers offers the opportunity to address the issue by performing comparative investigations on the effects of petroleum middle distillates on human skin xenografted to athymic (nude) mice. Such studies are being initiated.
在小鼠皮肤中诱导持续性表皮增生已被证明是多种化学物质（如佛波酯、蒽林、正十二烷和有机过氧化物）促癌活性的可靠预测指标（迪乔瓦尼，1992年）。本文所包含的结果表明，API 81 - 07和API 81 - 10这两种在小鼠皮肤中具有促癌活性的石油中间馏分，可诱导表皮增生和鸟氨酸脱羧酶（ODC）活性。其他石油中间馏分（无味轻质石油烃、轻质减压馏分和矿物密封油）也被证明具有这些活性。应该强调的是，这些观察结果与人类皮肤的相关性仍未解决；然而，这些短期生物标志物的可得性提供了一个机会，通过对石油中间馏分对移植到无胸腺（裸）小鼠身上的人类皮肤的影响进行比较研究来解决这个问题。此类研究正在展开。
