在比利时新鲁汶的CYCLONE回旋加速器产生的85兆电子伏特质子束中进行放射生物学有效性的测量。

Measurements of radiobiological effectiveness in the 85 MeV proton beam produced at the cyclotron CYCLONE of Louvain-la-Neuve, Belgium.

作者信息

Gueulette J, Grégoire V, Octave-Prignot M, Wambersie A

机构信息

Université Catholique de Louvain, Service de Radiothérapie-Oncologie, Cliniques Universitaires St-Luc, Bruxelles, Belgium.

出版信息

Radiat Res. 1996 Jan;145(1):70-4.

PMID:8532839

Abstract

The RBE of the 85 MeV proton beam produced at the cyclotron of Louvain-la-Neuve using 60Co gamma rays as the reference radiation was determined for survival of Chinese hamster ovary cells in vitro and for intestinal crypt regeneration in mice in vivo. Cell survival curves determined at different depths yielded, for a surviving fraction (SF) of 0.01, RBE values of 1.11 +/- 0.05 at the initial plateau of the unmodulated beam, 1.10 +/- 0.03 at the middle of a 0.5-cm spread-out Bragg peak (SOBP), 1.03 +/- 0.03 at the beginning of a 3-cm SOBP and 1.07 +/- 0.03 at the end of a 3-cm SOBP. The highest RBE values were obtained at the middle of the 0.5-cm SOBP and at the end of the 3-cm SOBP (RBE = 1.22 and 1.16, respectively, at SF = 0.5), although the variations are not statistically significant. Irradiations with 3-Gy fractions separated by an interval of 3.5 h yielded RBEs of 1.11 +/- 0.30 and 0.90 +/- 0.32 at the initial plateau and at the middle of the 0.5-cm SOBP, respectively. Irradiations of mice at the middle of the 3-cm SOBP yielded an RBE of 1.08 +/- 0.03 for 20 regenerated crypts at a proton dose of 12.3 Gy.

摘要

以60Coγ射线作为参考辐射，测定了在鲁汶新大学回旋加速器产生的85 MeV质子束对体外培养的中国仓鼠卵巢细胞存活及体内小鼠肠隐窝再生的相对生物学效应（RBE）。在不同深度测定的细胞存活曲线显示，对于0.01的存活分数（SF），在未调制束的初始平台期，RBE值为1.11±0.05；在0.5 cm扩展布拉格峰（SOBP）中部，RBE值为1.10±0.03；在3 cm SOBP开始时，RBE值为1.03±0.03；在3 cm SOBP结束时，RBE值为1.07±0.03。在0.5 cm SOBP中部和3 cm SOBP结束时获得了最高的RBE值（在SF = 0.5时，RBE分别为1.22和1.16），尽管这些变化无统计学意义。以间隔3.5小时的3 Gy分次照射，在初始平台期和0.5 cm SOBP中部的RBE分别为1.11±0.30和0.90±0.32。在3 cm SOBP中部对小鼠进行照射，质子剂量为12.3 Gy时，20个再生隐窝的RBE为1.08±0.03。