犬红细胞：细胞外ATP存在时的钠和钾扩散电位
Dog red blood cells: Na and K diffusion potentials with extracellular ATP.
作者信息
Parker J C, Castranova V, Goldfinger J M
出版信息
J Gen Physiol. 1977 Apr;69(4):417-30. doi: 10.1085/jgp.69.4.417.
Abstract
External ATP causes a prompt increase in the Na and K permeability of dog red blood cells. By manipulating intra- and extracellular ion composition it is possible to observe ATP-induced net fluxes which can be explained in terms of the contribution of Na or K diffusion potentials to the membrane potential. Measurements of membrane voltage by a fluorescent dye technique confirm the existence of such potentials. A rough calculation of chloride permeability gives a value of the order of 10(-8) cm/s, which agrees with results in other species. The cells appear to be somewhat more permeable to bromide than to chloride.
摘要
外源性三磷酸腺苷（ATP）可使犬红细胞的钠和钾通透性迅速增加。通过控制细胞内和细胞外离子组成，能够观察到ATP诱导的净通量，这可以根据钠或钾扩散电位对膜电位的贡献来解释。采用荧光染料技术测量膜电压证实了这种电位的存在。对氯离子通透性的粗略计算得出的值约为10^(-8) 厘米/秒，这与其他物种的结果一致。细胞对溴离子的通透性似乎比对氯离子的通透性略高。
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