Müller-Hermelink H K, Ott G, Ott M, Greiner A
Pathologisches Institut, Universität Würzburg.
Praxis (Bern 1994). 1995 Nov 28;84(48):1416-22.
Primary extranodal lymphomas of the stomach represent a fascinating object of investigation for clinicians and basic scientists. Possibly multifocal clonal populations of lymphocytes develop, which progress to highly malignant lymphomas over many years, starting from a previous reactive disease, commonly an Helicobacter-pylori-associated chronic gastritis or an organ related autoimmune disease in case of other sites of MALT lymphomas. In early stages of clonally restrained NHL of low malignancy of the MALT type a complete tumor regression can be achieved by elimination of the triggering agent Helicobacter pylori. At least a long standing remission is expected. The site and the frequency of relapse cannot be predicted until now. Basic requirement for the treatment by eradication of Helicobacter is the doubtless and well documented diagnosis of a low malignant NHL, based on immunohistological++ and molecular biologic findings, to prove scientifically the efficacy of this treatment. This will establish the basis to assess the stage and the grade of a primary gastric lymphoma in the future.
胃原发性结外淋巴瘤是临床医生和基础科学家极感兴趣的研究对象。可能会出现多灶性淋巴细胞克隆群体，它们从先前的反应性疾病开始，通常是幽门螺杆菌相关的慢性胃炎，或者在其他黏膜相关淋巴组织（MALT）淋巴瘤部位的器官相关自身免疫性疾病，经过多年发展为高度恶性淋巴瘤。在MALT型低恶性克隆性受限非霍奇金淋巴瘤（NHL）的早期阶段，通过消除触发因素幽门螺杆菌可实现肿瘤完全消退。至少有望实现长期缓解。到目前为止，复发部位和频率尚无法预测。通过根除幽门螺杆菌进行治疗的基本要求是基于免疫组织化学和分子生物学结果，对低恶性NHL进行明确且有充分记录的诊断，以科学证明这种治疗的疗效。这将为未来评估原发性胃淋巴瘤的分期和分级奠定基础。
