Touze J E, Keundjian A, Fusai T, Doury J C
Medical Department, Tropical Institute for French Army, Le Pharo, Marseille, France.
Trop Med Parasitol. 1995 Sep;46(3):158-60.
Two antimalarial prophylactic regimens were compared in 17 healthy volunteers. Regimen A consisted of daily ingestion of a single capsule containing 100 mg base chloroquine (CQ) and 200 mg proguanil (PG). Regimen B consisted of daily ingestion of separate tablets of CQ (100 mg base) and PG (two 100 mg tablets). Both treatments lasted for 12 days. Effective chloroquine levels were reached after 72 hours with both regimens (49.9 ng/ml for treatment A and 36.7 ng/ml for treatment B). Proguanil and cycloguanil plasma levels were significantly lower on sampling obtained at H3 (three hours later) and H6 (six hours later) on day 1 in the regimen A (p < 0.002). Thereafter there were no significant difference between the two regimens. Both regimens were well tolerated, but regimen A using the capsule appeared better accepted and facilitates compliance.
在17名健康志愿者中比较了两种抗疟预防方案。方案A为每日服用一粒含100mg碱化氯喹（CQ）和200mg氯胍（PG）的胶囊。方案B为每日分别服用CQ（100mg碱化）片和PG（两片100mg片剂）。两种治疗均持续12天。两种方案在72小时后均达到有效的氯喹水平（方案A为49.9ng/ml，方案B为36.7ng/ml）。在方案A中，第1天在H3（3小时后）和H6（6小时后）采样时，氯胍和环氯胍的血浆水平显著较低（p<0.002）。此后，两种方案之间无显著差异。两种方案耐受性均良好，但使用胶囊的方案A似乎更易被接受且有助于提高依从性。
