Walker G C
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
Trends Biochem Sci. 1995 Oct;20(10):416-20. doi: 10.1016/s0968-0004(00)89091-x.
Studies of Escherichia coli have revealed that most mutagenesis resulting from exposure to UV radiation and various chemicals (SOS mutagenesis) requires the operation of a specialized system involving the UmuD', UmuC, RecA and DNA polymerase III proteins, which allows translesion synthesis to occur on damaged DNA templates. The SOS mutagenesis system is induced by DNA damage and is subject to elaborate regulatory control involving both transcriptional derepression and post-translational activation and inhibition. The implications of the E. coli SOS mutagenesis system for mutagenesis in other organisms are discussed.
对大肠杆菌的研究表明，暴露于紫外线辐射和各种化学物质所导致的大多数诱变作用（SOS诱变）需要一个涉及UmuD'、UmuC、RecA和DNA聚合酶III蛋白的特殊系统发挥作用，该系统能使跨损伤合成在受损的DNA模板上发生。SOS诱变系统由DNA损伤诱导，并受到包括转录去抑制以及翻译后激活和抑制在内的精细调控。本文讨论了大肠杆菌SOS诱变系统对其他生物体诱变作用的影响。
