Robert M, Roux J O, Boularan A M, Bourelly F, Monnier L, Grasset D
Urology Department, Hôpital Lapeyronie, Montpellier, France.
Urol Int. 1995;55(2):88-92. doi: 10.1159/000282758.
Different indices of the risk of urinary calcium oxalate crystallization were compared to determine their usefulness in detecting the stone-formers particularly prone to recurrence. Urine volume and calcium, oxalate, citrate, magnesium or creatinine were determined in 55 patients presenting with an idiopathic calcium oxalate urolithiasis, as well as in 50 control subjects. On 24-hour urine samples, these elements allowed for the calculation and comparison of different indices of lithogenous risk as proposed by Parks and Tiselius. Both Parks' indices and the urinary citrate-calcium ratio varied significantly between the two groups, but conversely Tiselius' indices were statistically comparable. The three Tiselius' indices taking the 24-hour urine volume into account were also strongly correlated. Parks' index and the urinary citrate-calcium ratio are highly discriminating and potentially relevant to select the stone-formers with a high risk of relapse. Tiselius' indices basically reflect urinary calcium oxalate saturation, and can only be used clinically to control the treatment interfering with this. In this respect, the formula based simply on urine volume, calcium and oxalate over 24 h (Ca0.71.Ox.V-1.2) appears to be sufficient.
比较了草酸钙尿结晶风险的不同指标，以确定它们在检测特别容易复发的结石形成者方面的有用性。对55例特发性草酸钙尿路结石患者以及50例对照者的尿量、钙、草酸盐、柠檬酸盐、镁或肌酐进行了测定。对于24小时尿液样本，这些元素可用于计算和比较Parks和Tiselius提出的不同结石形成风险指标。两组之间Parks指标和尿柠檬酸盐 - 钙比值均有显著差异，但相反，Tiselius指标在统计学上具有可比性。考虑24小时尿量的三个Tiselius指标也高度相关。Parks指标和尿柠檬酸盐 - 钙比值具有高度鉴别性，可能有助于选择复发风险高的结石形成者。Tiselius指标基本反映草酸钙尿饱和度，临床上只能用于控制干扰此过程的治疗。在这方面，仅基于24小时尿量、钙和草酸盐的公式（Ca0.71.Ox.V - 1.2）似乎就足够了。
