Gotoh T
Department of Ophthalmology, Iwate Medical University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1995 Oct;99(10):1145-50.
In order to evaluate the effect of dextromethorphan (DEX), an antagonist of N-methyl-D-aspartate receptors, on ischemic damage in the detached retina, transretinal electrical responses (trans-retinal electroretinogram: TR-ERG) to photic stimulation were recorded from the detached retina of rabbit eyes in vitro. In experiment 1, 0.1 ml of 0.1% DEX was injected into the subretinal space to produce retinal detachment (RD) of 8 mm diameter (DEX group). For the control, the same volume of Hanks' solution was injected instead of DEX (control group). In experiment 2, 0.1 ml of 0.1% DEX was dropped onto retina, and RD was produced by injecting 0.1 ml of Hanks' solution into the subretinal space (DEX group). For the control, the same volume of saline was dropped onto the retina instead of DEX (control group). In experiment 1, the averaged b-wave amplitude of the TR-ERG decreased significantly (p < 0.01) at 3 hrs after RD in the control group, but it was almost stable and did not show significant decrease in the DEX group. In experiment 2, the averaged b-wave amplitude of the ERG decreased significantly (p < 0.05) at 2 hrs after the RD in the control, but showed no significant decrease even at 3 hrs after RD in the DEX group. These results indicate that DEX injected into the subretinal space and dropped onto the retina before producing RD may reduce ischemic damage in the detached retina.
为了评估N-甲基-D-天冬氨酸受体拮抗剂右美沙芬（DEX）对视网膜脱离时缺血性损伤的影响，在体外记录了兔眼视网膜脱离后对光刺激的经视网膜电反应（经视网膜视网膜电图：TR-ERG）。在实验1中，将0.1 ml 0.1%的DEX注入视网膜下间隙，造成直径8 mm的视网膜脱离（DEX组）。作为对照，注入相同体积的汉克斯溶液代替DEX（对照组）。在实验2中，将0.1 ml 0.1%的DEX滴在视网膜上，然后通过向视网膜下间隙注入0.1 ml汉克斯溶液造成视网膜脱离（DEX组）。作为对照，将相同体积的生理盐水滴在视网膜上代替DEX（对照组）。在实验1中，对照组视网膜脱离后3小时TR-ERG的平均b波振幅显著降低（p<0.01），但DEX组几乎稳定，未显示出显著降低。在实验2中，对照组视网膜脱离后2小时ERG的平均b波振幅显著降低（p<0.05），但DEX组即使在视网膜脱离后3小时也未显示出显著降低。这些结果表明，在造成视网膜脱离之前将DEX注入视网膜下间隙并滴在视网膜上，可能会减少视网膜脱离时的缺血性损伤。
