Ahman M, Holmström M, Ingelman-Sundberg H
Department of Medicine, Karolinska Institute, Sweden.
Am J Ind Med. 1995 Oct;28(4):541-50. doi: 10.1002/ajim.4700280409.
Exposure to wood dust can cause allergic and nonallergic rhinitis. Inflammatory markers [cells, albumin, tryptase, and eosinophil cationic protein (ECP)] were examined in nasal lavage fluid (NAL) sampled from 24 Industrial Arts (IA) teachers exposed to wood dust and other irritants and from 24 control subjects. The IA teachers had more nasal complaints but they did not differ significantly from the controls regarding ECP concentration (median 4.1 and 4.7 micrograms/L, respectively), albumin concentration (median 30.7 and 20.7 g/L), and percentage of neutrophils (median 56 and 34) in NAL. Tryptase was not detected. No marked inflammation was thus found, but the albumin concentration was higher in subjects reporting nasal stuffiness. In the IA teachers, a relationship between the percentage of neutrophils and the number of classes during the working week was found (Spearman's rank correlation coefficient 0.53, p < 0.01) indicating a possibility of wood-dust-related inflammatory effects on the nasal mucosa.
接触木尘可导致过敏性和非过敏性鼻炎。对24名接触木尘及其他刺激物的工艺美术（IA）教师和24名对照受试者采集的鼻灌洗液（NAL）中的炎症标志物[细胞、白蛋白、类胰蛋白酶和嗜酸性粒细胞阳离子蛋白（ECP）]进行了检测。IA教师有更多的鼻部不适症状，但在NAL中，他们的ECP浓度（中位数分别为4.1和4.7微克/升）、白蛋白浓度（中位数分别为30.7和20.7克/升）以及中性粒细胞百分比（中位数分别为56和34）与对照组相比无显著差异。未检测到类胰蛋白酶。因此未发现明显炎症，但报告有鼻塞症状的受试者白蛋白浓度较高。在IA教师中，发现中性粒细胞百分比与工作周内的课程节数之间存在关联（Spearman等级相关系数为0.53，p<0.01），这表明木尘可能对鼻黏膜产生炎症影响。
