[Evaluation of daunorubicin nephrotoxicity and effect of tocopherol and ascorbic acid on lesions induced in rat kidneys. II. Ultrastructural studies of kidney glomeruli].

Nephrotoxicity of daunorubicin in rats and effect of tocopherol and ascorbic acid on lesions induced in kidneys by daunorubicin were examined. The most significant ultrastructural changes in the glomeruli included the loss of foot processes in visceral epithelial cells and appearance of microvillous and vacuolar formations. The glomerular basement membrane showed minimal thickening. No beneficial influence of tocopherol and ascorbic acid on daunorubicin related nephrotoxicity was observed.