Paton M W, Sutherland S S, Rose I R, Hart R A, Mercy A R, Ellis T M
Avon Districts Agriculture Centre, Department of Agriculture, Northam, Western Australia.
Aust Vet J. 1995 Jul;72(7):266-9. doi: 10.1111/j.1751-0813.1995.tb03542.x.
The decrease in the prevalence of Corynebacterium pseudotuberculosis after two generations of vaccination against the disease it causes, was used to estimate the rate of control of caseous lymphadenitis (CLA). Three groups of 150 sheep, of which 50 in each group were artificially infected with C pseudotuberculosis and 100 in each group were uninfected sheep, were run separately for 40 months and shorn 5 times to promote the spread of CLA. One lot of 50 infected sheep and 2 lots of 100 uninfected sheep were vaccinated against CLA. The rate of spread of CLA was recorded. Sheep vaccinated against CLA and naturally exposed to infection had a 74% lower infection rate than unvaccinated sheep. Sheep vaccinated against CLA and exposed to only vaccinated infected sheep had a 97% lower infection rate. Unvaccinated sheep had a 76% infection rate, with 77% of the transmission occurring at the 4th and 5th shearings, without any discharging CLA abscesses being observed. This study supports the view that in Australian wool producing flocks, CLA spreads mainly from sheep with discharging lung abscesses to sheep with shearing cuts. Vaccinated sheep infected with CLA have 96% fewer lung abscesses compared with unvaccinated infected sheep and are therefore less likely to spread this disease to other sheep.
在针对由假结核棒状杆菌引起的疾病进行两代疫苗接种后，该病菌的流行率下降，以此来估计干酪性淋巴结炎（CLA）的控制率。将三组各150只绵羊分开饲养40个月，并剪毛5次以促进CLA的传播，其中每组50只绵羊人工感染假结核棒状杆菌，每组100只为未感染绵羊。对一组50只感染绵羊和两组100只未感染绵羊接种CLA疫苗。记录CLA的传播率。接种CLA疫苗且自然暴露于感染源的绵羊感染率比未接种疫苗的绵羊低74%。接种CLA疫苗且仅接触接种过疫苗的感染绵羊的绵羊感染率低97%。未接种疫苗的绵羊感染率为76%，77%的传播发生在第4次和第5次剪毛时，未观察到任何排出CLA脓肿的情况。本研究支持以下观点：在澳大利亚产毛羊群中，CLA主要从有排出性肺脓肿的绵羊传播到有剪毛伤口的绵羊。与未接种疫苗的感染绵羊相比，感染CLA的接种疫苗绵羊肺脓肿减少96%，因此将这种疾病传播给其他绵羊的可能性较小。
