Noskovic P, Faberová V, Fabianová M
Department of Biochemistry, Drug Research Institute, Modra, Slovak Republic.
Mol Chem Neuropathol. 1995 Jun-Aug;25(2-3):97-102. doi: 10.1007/BF02960904.
The authors studied the effects of a combination of pentoxifylline and nimodipine on cerebral lipid peroxidation in postischemic rat brain. Pentoxifylline (40 mg/kg) and nimodipine (3 mg/kg) were administered per os 30 min before 5 min of ischemia (four-vessel occlusion model of transient ischemia). The extent of peroxidation in brain tissue (cerebral cortex, hippocampus, striatum) was then estimated by assay of thiobarbituric acid reactive substances (TBARS). The concentration of TBARS was significantly lower in the cerebral cortex and hippocampus of the group treated with the combination of drugs than in untreated ischemic rats. However, this concentration was not significantly different from that found in the cerebral cortex and hippocampus of other groups premedicated with nimodipine or pentoxifylline alone. The tested drugs had no effect on TBARS in the striatum. The hypothesis that the combination of drugs would have a synergistic effect on postischemic lipid peroxidation was therefore not confirmed.
作者研究了己酮可可碱与尼莫地平联合应用对缺血后大鼠脑内脂质过氧化的影响。在缺血5分钟前30分钟经口给予己酮可可碱（40毫克/千克）和尼莫地平（3毫克/千克）（短暂缺血的四血管闭塞模型）。然后通过测定硫代巴比妥酸反应性物质（TBARS）来评估脑组织（大脑皮层、海马体、纹状体）中的过氧化程度。联合用药组大脑皮层和海马体中的TBARS浓度显著低于未治疗的缺血大鼠。然而，该浓度与单独预先给予尼莫地平或己酮可可碱的其他组大脑皮层和海马体中的浓度无显著差异。受试药物对纹状体中的TBARS无影响。因此，药物联合应用对缺血后脂质过氧化具有协同作用这一假设未得到证实。
