Crawford R J, Collins M A, Clipper D W, Prencipe M
Colgate-Palmolive Technology Center, Piscataway, New Jersey, USA.
J Clin Dent. 1994;5 Spec No:80-2.
The availability and stability of the active ingredients in a Sensitive/Tartar Control dentifrice have been evaluated in this study. The Sensitive/Tartar Control dentifrice contains 5% potassium nitrate as the anti-hypersensitivity agent, 0.243% sodium fluoride as the anti-caries agent, 2% tetrasodium pyrophosphate and 1.5% polyvinylmethyl ether/maleic acid (PVM/MA) copolymer as the antitartar system. The availability of potassium and fluoride from this dentifrice was tested and found to be acceptable in both freshly prepared and aged samples. Fluoride and potassium availability were also tested at dilutions similar to in vivo brushing levels, and the ability of the Sensitive/Tartar Control dentifrice to provide fluoride to enamel and reduce enamel solubility was measured. In these tests the Sensitive/Tartar Control dentifrice performed similarly to commercial fluoride dentifrices. Potassium availability was equal to Crest Sensitivity Protection, a product shown to be clinically effective against tooth sensitivity; fluoride availability and activity was shown to be equal to Crest Tartar Control, a product with published clinical anti-caries effectiveness.
本研究评估了一款敏感/防牙石牙膏中活性成分的有效性和稳定性。该敏感/防牙石牙膏含有5%的硝酸钾作为抗敏感剂、0.243%的氟化钠作为防龋剂、2%的焦磷酸四钠以及1.5%的聚乙烯甲基醚/马来酸（PVM/MA）共聚物作为防牙石体系。对该牙膏中钾和氟的有效性进行了测试，结果发现新鲜制备的样品和老化样品的有效性均令人满意。还在类似于体内刷牙水平的稀释度下测试了氟化物和钾的有效性，并测量了敏感/防牙石牙膏向牙釉质提供氟化物以及降低牙釉质溶解度的能力。在这些测试中，敏感/防牙石牙膏的表现与市售含氟牙膏相似。钾的有效性与佳洁士敏感保护牙膏相当，该产品已被证明对牙齿敏感具有临床疗效；氟化物的有效性和活性与佳洁士防牙石牙膏相当，该产品已公布具有临床防龋效果。
