Xu K P, Tsubota K
Department of Ophthalmology, Tokyo Dental College, Japan.
Br J Ophthalmol. 1995 Nov;79(11):1042-5. doi: 10.1136/bjo.79.11.1042.
The study sought to determine dynamic changes and theoretical bases of a clinical diagnostic test, the tear clearance rate.
Thirty four healthy subjects ranging in age from 22 to 84 years underwent examination of tear clearance rate, the Schirmer test with anaesthesia, as well as fluorophotometric measurement of tear turnover, tear volume, and tear flow. By applying 0.5% fluorescein into the conjunctival sac and subsequently measuring colour fades on a Schirmer strip, the tear clearance rate for assessing tear drainage was divided into nine grades. The results of the tear clearance rate were compared with those of the basal tear turnover and tear flow obtained from fluorophotometry.
Significant relations were found between the tear clearance rate and the basal tear turnover or tear flow (r = 0.91 and 0.79, respectively, p = 0.0001). Considering the grades of progression from low to high, each grade of tear clearance rate showed a 12.5% increase in basal tear turnover (3.59%/min) and tear flow (0.38 microliter/min). There was no significant correlation between age and the basal tear turnover, tear volume, tear flow, or the tear clearance rate.
The tear clearance rate is proposed as a simple and useful way to estimate basal tear turnover and tear flow, and measure tear drainage indirectly.
本研究旨在确定一种临床诊断测试——泪液清除率的动态变化及其理论基础。
对34名年龄在22至84岁之间的健康受试者进行泪液清除率检查、麻醉下的Schirmer试验，以及荧光光度法测量泪液更新、泪液量和泪液流量。通过将0.5%荧光素滴入结膜囊，随后测量Schirmer试纸上的颜色消退情况，将用于评估泪液引流的泪液清除率分为九个等级。将泪液清除率的结果与荧光光度法测得的基础泪液更新和泪液流量的结果进行比较。
发现泪液清除率与基础泪液更新或泪液流量之间存在显著相关性（r分别为0.91和0.79，p = 0.0001）。从低到高考虑进展等级，泪液清除率的每个等级显示基础泪液更新（3.59%/分钟）和泪液流量（0.38微升/分钟）增加12.5%。年龄与基础泪液更新、泪液量、泪液流量或泪液清除率之间无显著相关性。
泪液清除率被认为是一种简单而有用的方法，可用于估计基础泪液更新和泪液流量，并间接测量泪液引流。
