人血浆中芬替康唑的高效液相色谱（HPLC）/串联质谱测定法的建立与验证及其与HPLC-UV法的比较。
The development and validation of a high performance liquid chromatography (HPLC)/tandem mass spectrometry assay for fenticonazole in human plasma and comparison with an HPLC-UV method.
作者信息
Speed W, Long J M, Simmonds R J, Enos T A
机构信息
Upjohn Laboratories--Europe, West Sussex, UK.
出版信息
Rapid Commun Mass Spectrom. 1995;9(14):1452-6. doi: 10.1002/rcm.1290091424.
PMID:8534893
Abstract
A method is described for the determination of fenticonazole in human female plasma. The method utilizes high performance liquid chromatography coupled to atmospheric pressure positive-ion chemical ionization triple quadrupole mass spectrometry. Multiple reaction monitoring is employed for selectivity and sensitivity which enables quantification over the range 0.5-20 ng mL-1 with acceptable precision and accuracy. A comparison is made with an existing HPLC-UV assay and the utility of the technology of combined liquid chromatography and tandem mass spectometry for subnanogram per mL assays is discussed.
摘要
描述了一种测定女性人血浆中芬替康唑的方法。该方法采用高效液相色谱与大气压正离子化学电离三重四极杆质谱联用。采用多反应监测来提高选择性和灵敏度，从而能够在0.5 - 20 ng mL-1范围内进行定量，且具有可接受的精密度和准确度。将该方法与现有的HPLC - UV测定法进行了比较，并讨论了液相色谱和串联质谱联用技术在每毫升亚纳克级测定中的实用性。
相似文献
1
The development and validation of a high performance liquid chromatography (HPLC)/tandem mass spectrometry assay for fenticonazole in human plasma and comparison with an HPLC-UV method.人血浆中芬替康唑的高效液相色谱（HPLC）/串联质谱测定法的建立与验证及其与HPLC-UV法的比较。
Rapid Commun Mass Spectrom. 1995;9(14):1452-6. doi: 10.1002/rcm.1290091424.
2
The sensitive determination of abanoquil in blood by high-performance liquid chromatography/atmospheric pressure ionization mass spectrometry.采用高效液相色谱/大气压电离质谱法灵敏测定血液中的阿巴诺喹。
Biol Mass Spectrom. 1992 Nov;21(11):585-9. doi: 10.1002/bms.1200211110.
3
Employing atmospheric pressure photoionization in liquid chromatography/tandem mass spectrometry to minimize ion suppression and matrix effects for the quantification of venlafaxine and O-desmethylvenlafaxine.在液相色谱/串联质谱中采用大气压光电离以最小化离子抑制和基质效应来定量文拉法辛和O-去甲基文拉法辛。
Rapid Commun Mass Spectrom. 2007;21(10):1680-6. doi: 10.1002/rcm.3006.
4
Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry.使用湍流色谱法和串联质谱法测定人血浆和尿液中MK-0974的在线萃取分析高效方法开发策略。
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):64-73. doi: 10.1016/j.jchromb.2007.12.017. Epub 2008 Jan 4.
5
Validation study of assay method for DX-8951 and its metabolite in human plasma and urine by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.高效液相色谱/大气压化学电离串联质谱法测定人血浆和尿液中DX-8951及其代谢物的分析方法验证研究
Biomed Chromatogr. 2001 Apr;15(2):108-15. doi: 10.1002/bmc.44.
6
Determination of amiodarone and desethylamiodarone in horse plasma and urine by high-performance liquid chromatography combined with UV detection and electrospray ionization mass spectrometry.高效液相色谱结合紫外检测和电喷雾电离质谱法测定马血浆和尿液中的胺碘酮和去乙基胺碘酮。
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 May 19;836(1-2):47-56. doi: 10.1016/j.jchromb.2006.03.038. Epub 2006 Apr 17.
7
Determination of a novel substance P inhibitor in human plasma by high-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometric detection using single and triple quadrupole detectors.采用单四极杆和三重四极杆检测器的大气压化学电离质谱检测高效液相色谱法测定人血浆中一种新型P物质抑制剂
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Aug 5;807(2):243-50. doi: 10.1016/j.jchromb.2004.04.017.
8
Development and validation of bioanalytical methods for Imidafenacin (KRP-197/ONO-8025) and its metabolites in human plasma by liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):70-9. doi: 10.1016/j.jchromb.2007.02.047. Epub 2007 Mar 14.
9
Determination of dextromethorphan and its metabolite dextrorphan in human urine using high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry: a study of selectivity of a tandem mass spectrometric assay.采用高效液相色谱-大气压化学电离串联质谱法测定人尿中右美沙芬及其代谢产物右啡烷：串联质谱分析方法的选择性研究
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):297-308. doi: 10.1016/j.jchromb.2004.11.049.
10
An automated method for the simultaneous determination of pravastatin and its main metabolite in human plasma by high-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometry.一种通过高效液相色谱/大气压化学电离质谱法同时测定人血浆中普伐他汀及其主要代谢物的自动化方法。
Biomed Chromatogr. 1998 Sep-Oct;12(5):271-5. doi: 10.1002/(SICI)1099-0801(199809/10)12:5<271::AID-BMC746>3.0.CO;2-F.
引用本文的文献
1
Determination of fenticonazole in human plasma by HPLC-MS/MS and its application to pharmacokinetic studies.高效液相色谱-串联质谱法测定人血浆中的芬替康唑及其在药代动力学研究中的应用
J Pharm Anal. 2017 Feb;7(1):63-70. doi: 10.1016/j.jpha.2016.09.002. Epub 2016 Sep 8.
Zotero 插件