乳清蛋白对肠道Caco-2细胞单层紧密连接的稳定作用。
Stabilization of the tight junction of the intestinal Caco-2 cell monolayer by milk whey proteins.
作者信息
Hashimoto K, Takeda K, Nakayama T, Shimizu M
机构信息
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
出版信息
Biosci Biotechnol Biochem. 1995 Oct;59(10):1951-2. doi: 10.1271/bbb.59.1951.
PMID:8534990
Abstract
The tight junction (TJ) of the human intestinal Caco-2-SF monolayer was shown not to have been stably formed. TJ was stabilized by incubating the cell monolayer with beta-lactoglobulin (beta-Lg) and bovine serum albumin (BSA). Thus, the Caco-2-SF cell-culture system will provide a useful model for studying the factors which stabilize TJ and for investigating the mechanism of TJ regulation.
摘要
人肠道Caco-2-SF单层细胞的紧密连接（TJ）尚未稳定形成。通过用β-乳球蛋白（β-Lg）和牛血清白蛋白（BSA）孵育细胞单层来稳定TJ。因此，Caco-2-SF细胞培养系统将为研究稳定TJ的因素以及研究TJ调节机制提供一个有用的模型。
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