Maalej M, Daoud J, Bouaouina N, Benna F, Frikha H, Jallouli M, Ellouze R, Ben Romdhane K B, Cammoun M, Ben Attia R B
Service de cancérologie-radiothérapie, Institut Salah-Azaiz, Tunis.
Bull Cancer. 1995 Sep;82(9):728-31.
Nasopharyngeal carcinoma (NPC) is the primary cancer of the head and neck localisations in the Salah Azaiz Institute (Tunisia). From 1970 to 1987, 80 patients with histologically proven T4 N0 NPC, were treated with exclusive radiation (70-75 Gy to the primary lesion and 50-55 Gy to cervical lymph nodes). The T4 N0 represents 7% of all NPC and 16% of the T4 treated in our Institute. Ninety percent of the patients are over 20 years old with a mean age of 52 years. The sex-ratio was 4:1. Extension to the brain was observed in 55% of the cases. Local control was 70% at 2 months after the end of irradiation. The actuarial survival at 5 years was 47%. Distant metastasis represent 13% (30% of all NPC). The main failure of treatment was local recurrence. The T4 N0 is probably a particular entity concerning the age, the response to radiotherapy and the low rate of distant metastasis.
鼻咽癌（NPC）是突尼斯萨拉赫·阿扎伊兹研究所头颈部区域的原发性癌症。1970年至1987年期间，80例经组织学证实为T4 N0期鼻咽癌的患者接受了单纯放疗（原发灶70 - 75 Gy，颈部淋巴结50 - 55 Gy）。T4 N0期病例占所有鼻咽癌病例的7%，占本研究所治疗的T4期病例的16%。90%的患者年龄超过20岁，平均年龄为52岁。男女比例为4:1。55%的病例观察到肿瘤侵犯至脑部。放疗结束2个月时局部控制率为70%。5年精算生存率为47%。远处转移率为13%（占所有鼻咽癌的30%）。治疗的主要失败原因是局部复发。T4 N0期在年龄、对放疗的反应以及远处转移率较低方面可能是一个特殊的类型。
