Sainte-Marie J, Vidal M, Philippot J R, Bienvenüe A
URA-CNRS 1856, Dept Biologie Santé Bat 24, Montpellier, France.
Biochem Mol Biol Int. 1995 Aug;36(6):1161-8.
The internalization and recycling kinetics of transferrin receptors in leukemic lymphocytes (L2C) differed in the absence or presence of ligand. At 37 degrees C in the absence of ligand, transferrin receptors were mainly distributed internaly. We demonstrated, using a sepharose-bead-Tf complex, the rapid recycling of unoccupied internal transferrin receptors was correlated with ligand binding to surface receptors. The recycling amplitude was related to the occupancy of iron ligated transferrin to plasma membrane surface receptors. Contrary to the results obtained with other cells, redistribution of Tf receptors was not triggered by binding of other ligands to their receptors.
白血病淋巴细胞（L2C）中转铁蛋白受体的内化和再循环动力学在有无配体的情况下有所不同。在37摄氏度且无配体时，转铁蛋白受体主要分布在细胞内。我们使用琼脂糖珠 - 转铁蛋白复合物证明，未占据的细胞内转铁蛋白受体的快速再循环与配体与表面受体的结合相关。再循环幅度与铁结合转铁蛋白对质膜表面受体的占有率有关。与其他细胞获得的结果相反，其他配体与其受体的结合并未引发转铁蛋白受体的重新分布。
