Chau N P, Hansson L, Petitet A, Safar M E
Centre de Bioinformatique, University of Paris 7, INSERM U263, Paris, France.
Blood Press Suppl. 1995;3:26-30.
To report a large set of observations on blood pressure and blood lipids including high-density lipoprotein cholesterol in male and female hypertensive subjects aged 60 years or above.
Data on blood pressure (BP), total cholesterol (C), and high-density lipoprotein cholesterol (HDL-C) were made available on 5310 hypertensive subjects aged 60-97 years, from a European study on the effects of urapidil, a multifactorial antihypertensive agent (alpha 1-adrenoceptor antagonist+control 5HT1A-receptor stimulant). Observations before treatment were analysed to assess the male-female difference and the changes with age of BP and serum lipids. The subjects were divided into 7 groups, aged 60-62, 63-65, 66-68, 69-71, 72-76, 77-79, and 80+, respectively, and a 2-factor ANOVA (sex and age groups) was used.
Systolic BP increased with increasing age in both sexes (p < 0.0001). Over the whole age range, SBP was higher in women than in men (p < 0.0001). Diastolic BP remained unchanged in men and decreased with increasing age in women (p < 0.001). The C level was almost the same in men as in women, but tended to decrease with increasing age in women (p < 0.05). HDL-C was unchanged in men, but increased with increasing age in women (p < 0.006). In all age ranges, the HDL-C level was higher in women than in men (p < 0.0001).
This study reports observations on BP and serum lipids in a large sample of hypertensives subjects aged 60-97 years. This type of data, especially on high-density lipoprotein cholesterol, is rare in the elderly.
报告对60岁及以上男性和女性高血压患者的血压和血脂（包括高密度脂蛋白胆固醇）进行的大量观察结果。
来自一项关于多因素抗高血压药物乌拉地尔（α1肾上腺素能受体拮抗剂 + 5HT1A受体激动剂）作用的欧洲研究，提供了5310名年龄在60 - 97岁的高血压患者的血压（BP）、总胆固醇（C）和高密度脂蛋白胆固醇（HDL-C）数据。分析治疗前的观察结果，以评估男女差异以及血压和血脂随年龄的变化。将受试者分为7组，年龄分别为60 - 62岁、63 - 65岁、66 - 68岁、69 - 71岁、72 - 76岁、77 - 79岁和80岁及以上，并使用双因素方差分析（性别和年龄组）。
收缩压在两性中均随年龄增长而升高（p < 0.0001）。在整个年龄范围内，女性的收缩压高于男性（p < 0.0001）。男性舒张压保持不变，女性舒张压随年龄增长而降低（p < 0.001）。男性和女性的C水平几乎相同，但女性C水平随年龄增长有下降趋势（p < 0.05）。男性HDL-C水平不变，女性HDL-C水平随年龄增长而升高（p < 0.006）。在所有年龄范围内，女性的HDL-C水平高于男性（p < 0.0001）。
本研究报告了对60 - 97岁大量高血压患者的血压和血脂的观察结果。这类数据，尤其是关于高密度脂蛋白胆固醇的数据，在老年人中很少见。
