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高血压和血压正常的绝经前女性的胰岛素抵抗与交感神经系统活性

Insulin resistance and sympathetic nervous system activity in hypertensive and normotensive premenopausal women.

作者信息

Nordby G, Moan A, Kjeldsen S E, Eide I K, Os I

机构信息

Department of Internal Medicine, Ullevaal Hospital, University of Oslo, Norway.

出版信息

Blood Press. 1995 Sep;4(5):287-92. doi: 10.3109/08037059509077609.

DOI:10.3109/08037059509077609
PMID:8535550
Abstract

The aim of the present study was to compare insulin sensitivity and catecholamine responses to insulin in lean, hypertensive (HT) and normotensive (NT) premenopausal women. HT (BP 149 5/99 +/- 2 mmHg, n = 14) and NT (BP 128 +/- 4/81 +/- 2 mmHg, n = 12) were matched for age (46 +/- 1 vs. 47 +/- 1 years) and body mass index. Insulin sensitivity was determined by fasting serum insulin, glucose disposal rate (GDR) and insulin sensitivity index (GDR/I) using euglycemic hyperinsulinemic glucose clamp technique. Sympathetic nervous system activity was assessed by plasma adrenaline and noradrenaline in arterialized venous blood at baseline and during euglycemic hyperinsulinemic glucose clamp. Insulin sensitivity index correlated negatively with total cholesterol in HT (r = -0.57, p < 0.05) and with body mass index (r = -0.42, p < 0.05, n = 26). The response in catecholamines to euglycemic hyperinsulinemia in HT differed from NT with an increase both in noradrenaline and adrenaline. Blood pressure and heart rate responses, however, did not differ between HT and NT. Fasting serum glucose did not differ between the two groups (4.7 +/- 0.1 mmol/l in HT vs. 4.9 +/- 0.1 mmol/l in NT), nor did fasting serum insulin (16 2 mU/l vs. 13 mU/l). Glucose disposal rate (8.8 +/- 0.5 vs. 8.7 +/- 0.7 mg kg-1 body weight min-1) and insulin sensitivity index were similar (7.3 +/- 0.8 vs. 7.6 +/- 0.8 arbitrary units). We conclude that in lean, premenopausal hypertensive women insulin sensitivity is not reduced compared with age- and weight-matched normotensive women, but the hypertensives respond to hyperinsulinemia with increased plasma catecholamines, i.e. sympathetic nervous systemic activity. Also, insulin sensitivity correlates negatively with serum cholesterol. Thus, an insulin-hyperadrenergic interaction may possibly be involved as a pathogenetic factor in lean hypertensive women.

摘要

本研究的目的是比较体型偏瘦的绝经前高血压(HT)女性和血压正常(NT)女性对胰岛素的敏感性以及儿茶酚胺对胰岛素的反应。HT组(血压149±5/99±2 mmHg,n = 14)和NT组(血压128±4/81±2 mmHg,n = 12)在年龄(46±1岁对47±1岁)和体重指数方面进行了匹配。使用正常血糖高胰岛素葡萄糖钳夹技术,通过空腹血清胰岛素、葡萄糖处置率(GDR)和胰岛素敏感性指数(GDR/I)来测定胰岛素敏感性。通过在基线时以及正常血糖高胰岛素葡萄糖钳夹期间采集动脉化静脉血中的血浆肾上腺素和去甲肾上腺素,来评估交感神经系统活性。在HT组中,胰岛素敏感性指数与总胆固醇呈负相关(r = -0.57,p < 0.05),与体重指数也呈负相关(r = -0.42,p < 0.05,n = 26)。HT组对正常血糖高胰岛素血症时儿茶酚胺的反应与NT组不同,去甲肾上腺素和肾上腺素均增加。然而,HT组和NT组之间的血压和心率反应没有差异。两组之间空腹血清葡萄糖无差异(HT组为4.7±0.1 mmol/l,NT组为4.9±0.1 mmol/l),空腹血清胰岛素也无差异(分别为16±2 mU/l和13 mU/l)。葡萄糖处置率(8.8±0.5对8.7±0.7 mg·kg-1体重·min-1)和胰岛素敏感性指数相似(分别为7.3±0.8和7.6±0.8任意单位)。我们得出结论,在体型偏瘦的绝经前高血压女性中,与年龄和体重匹配的血压正常女性相比,胰岛素敏感性并未降低,但高血压女性对高胰岛素血症的反应是血浆儿茶酚胺增加,即交感神经系统活性增加。此外,胰岛素敏感性与血清胆固醇呈负相关。因此,胰岛素 - 高肾上腺素能相互作用可能作为体型偏瘦的高血压女性的致病因素而参与其中。

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