Williams H J
Division of Rheumatology, University of Utah School of Medicine, Salt Lake City, USA.
Br J Rheumatol. 1995 Nov;34 Suppl 2:96-9.
This article discusses the use of combinations of disease-modifying antirheumatic drugs (DMARDs) in the treatment of rheumatoid arthritis (RA). Patients with RA have a disease that can be disabling and life threatening and current therapies do not prevent these complications. The need for more aggressive therapy is apparent. The rationale for combinations of DMARDs is explored and the efficacy and safety of reported combinations is summarized. The variables to be reviewed in selecting a combination of DMARDs are examined. Newer approaches employing multiple DMARDs will be considered.
本文讨论了改善病情抗风湿药（DMARDs）联合用药在类风湿关节炎（RA）治疗中的应用。类风湿关节炎患者所患疾病可能导致残疾甚至危及生命，而目前的治疗方法无法预防这些并发症。显然需要更积极的治疗。本文探讨了DMARDs联合用药的基本原理，并总结了已报道的联合用药的疗效和安全性。研究了选择DMARDs联合用药时需考虑的变量。还将考虑采用多种DMARDs的新方法。
