Otnes B, Harvei S, Fosså S D
Section of Urology, Baerum Hospital, Norway.
Br J Urol. 1995 Nov;76(5):587-94. doi: 10.1111/j.1464-410x.1995.tb07783.x.
To quantify the need for treatment and care in patients with conservatively treated prostate cancer.
All men who had been diagnosed with prostate cancer in a defined geographical area and who died within the period 1987-91 were identified. Patients treated with curative intent were excluded. Medical records from hospitals, nursing homes and community nurses for the period from diagnosis until death were scrutinized for the remaining 174 patients.
Of the 174 patients, 95% were symptomatic at diagnosis and 62% died from prostate cancer. All but two patients were hospitalized for prostate cancer, for a mean of 1 month. Thirty-six per cent needed regular nursing in nursing homes or by community nurses at home. Complications requiring hospitalization or long-term catheterization occurred in 49%. Prostatic surgery was performed in 66% and androgen ablation in 76% of the patients; palliative irradiation was given to 16% and 50% received analgesics regularly, including opiates or equivalents in 37%. Prednisone was given to 29%, after the failure of androgen ablation.
Our findings demonstrate the considerable burden imposed both on patients and health-care resources by symptomatic prostate cancer, conservatively treated. There are few data available for comparison.
量化保守治疗的前列腺癌患者的治疗和护理需求。
确定在特定地理区域内被诊断为前列腺癌且于1987 - 1991年期间死亡的所有男性。排除接受根治性治疗的患者。对其余174例患者从诊断直至死亡期间来自医院、疗养院和社区护士的医疗记录进行了详细审查。
174例患者中，95%在诊断时有症状，62%死于前列腺癌。除两名患者外，所有患者均因前列腺癌住院，平均住院1个月。36%的患者需要在疗养院或由社区护士在家中进行定期护理。49%的患者出现需要住院治疗或长期插管的并发症。66%的患者接受了前列腺手术，76%的患者接受了雄激素去除治疗；16%的患者接受了姑息性放疗，50%的患者定期接受镇痛药治疗，其中37%使用了阿片类药物或等效药物。在雄激素去除治疗失败后，29%的患者接受了泼尼松治疗。
我们的研究结果表明，保守治疗的有症状前列腺癌给患者和医疗资源都带来了相当大的负担。可供比较的数据很少。
