Yoshino S, Kato M, Okada K
Department of Urology, Saitama Medical School, Japan.
Int J Urol. 1995 Jul;2(3):156-60. doi: 10.1111/j.1442-2042.1995.tb00445.x.
It has been postulated that tumors beyond a certain size are dependent on angiogenesis, which might also be related to distant metastasis. We therefore assessed the prognostic significance of tumor microvasculature in renal cell carcinoma.
Tumor specimens from 84 patients with primary renal cell carcinoma were examined by immunohistochemical staining for factor VIII. Individual microvessels were counted in a 200 x field overlying the area of highest neovacularization.
The mean number of microvessels in patients with metastases was significantly higher than that in patients who were disease-free for more than three years (P = 0.004). The survival of patients with less than 30 microvessels per 200 x field was significantly higher than that of patients with more than 30 microvessels per 200 x field (P = 0.007). Multivariate analyses revealed that these microvessel counts were the only significant predictor of prognosis in 45 patients with T1-2 and M0 tumors (P = 0.028).
Assessment of tumor microvasculature is therefore probably one of the most important prognostic predictors in renal cell carcinoma.
据推测，超过一定大小的肿瘤依赖于血管生成，这也可能与远处转移有关。因此，我们评估了肾细胞癌中肿瘤微血管的预后意义。
对84例原发性肾细胞癌患者的肿瘤标本进行免疫组织化学染色检测因子VIII。在新生血管形成最明显区域的一个200倍视野中计数单个微血管。
发生转移患者的微血管平均数显著高于无病生存期超过三年的患者（P = 0.004）。每200倍视野中微血管少于30个的患者生存率显著高于每200倍视野中微血管多于30个的患者（P = 0.007）。多变量分析显示，在45例T1-2和M0期肿瘤患者中，这些微血管计数是唯一显著的预后预测指标（P = 0.028）。
因此，评估肿瘤微血管可能是肾细胞癌最重要的预后预测指标之一。
