在一例急性非淋巴细胞白血病中，8号染色体六体性和11号染色体三体性是两个核型独立的克隆的特征。常规细胞遗传学和荧光原位杂交研究。

Hexasomy of chromosome 8 and trisomy of chromosome 11 characterize two karyotypically independent clones in a case of acute non-lymphocytic leukemia. Conventional cytogenetic and FISH investigation.

作者信息

Trakhtenbrot L, Rosner E, Gipsh N, Berman S, Sofer O, Brok-Simoni F, Rechavi G, Ben-Bassat I

机构信息

Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.

出版信息

Cancer Genet Cytogenet. 1995 Nov;85(1):1-4. doi: 10.1016/0165-4608(95)00107-7.

DOI:10.1016/0165-4608(95)00107-7

PMID:8536231

Abstract

A case of ANLL following a myelodysplastic syndrome, probably resulting from occupational exposure to ionizing irradiation, with two cytogenetically unrelated clones, hexasomy 8 and trisomy 11, was investigated by conventional cytogenetics and FISH. Significant quantitative differences between data obtained by metaphase and interphase analysis of the hexasomy 8 clone were observed. A difference in the sensitivity to chemotherapy of the two clones was found: while the hexasomy 8 clone markedly decreased in response to treatment, the trisomy 11 clone remained unchanged.

摘要

1例骨髓增生异常综合征后发生的急性非淋巴细胞白血病，可能因职业性暴露于电离辐射所致，存在两个细胞遗传学不相关的克隆，即8号染色体六体和11号染色体三体，通过传统细胞遗传学和荧光原位杂交技术进行了研究。观察到8号染色体六体克隆在中期和间期分析所获数据之间存在显著的数量差异。发现两个克隆对化疗的敏感性存在差异：8号染色体六体克隆对治疗反应明显降低，而11号染色体三体克隆则保持不变。