van Ahlen H, Piechota H J, Kias H J, Brennemann W, Klingmüller D
Department of Urology, University of Münster, Germany.
Eur Urol. 1995;28(3):246-50. doi: 10.1159/000475059.
Opioids have an inhibitory effect on sexual functions in both animals and humans. Twenty patients with idiopathic, nonvascular, nonneurogenic erectile dysfunction were treated with the opiate receptor antagonist naltrexone in a randomized, placebo-controlled, double-blind study for 8 weeks. Libido and frequency of sexual intercourse were not significantly altered, but early-morning erections increased significantly under naltrexone therapy. This response was not related to levels of androgens or gonadotropins, neither was it dose dependent. There was no change in any of the measured parameters under placebo. Further clinical studies with the substance should be conducted to evaluate its possible role in the oral treatment of male impotence.
阿片类药物对动物和人类的性功能均有抑制作用。在一项随机、安慰剂对照、双盲研究中，20例特发性、非血管性、非神经源性勃起功能障碍患者接受了阿片受体拮抗剂纳曲酮治疗，为期8周。性欲和性交频率没有显著改变，但在纳曲酮治疗下晨勃显著增加。这种反应与雄激素或促性腺激素水平无关，也不是剂量依赖性的。安慰剂治疗下所有测量参数均无变化。应对该物质进行进一步的临床研究，以评估其在男性阳痿口服治疗中的可能作用。
