Perola M, Sajantila A, Sarti C, Stengård J, Tamminen M, Puska P, Huttunen J, Tuomilehto J, Peltonen L
Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland.
Genet Epidemiol. 1995;12(4):391-9. doi: 10.1002/gepi.1370120407.
The deletion/deletion genotype of the insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been suggested to be a risk factor for myocardial infarction (MI). The objective of this study was to evaluate whether genotype distributions of the I/D polymorphism of the ACE gene are different between individuals from high-risk and low-risk areas for coronary heart disease in the genetically isolated population of Finland and to assess the impact of this genetic risk factor by comparing individuals with different parental histories of MI. Representative population-based samples of middle-aged men (n = 363) and women (n = 358) from two areas of Finland were used. The area had a borderline significant effect on the prevalence of the genotype DD (beta = 0.35, SE = 0.16, X2 = 470, df = 1, P = 0.03), the DD genotype being more prevalent in eastern Finland (the high-risk area). The II genotype was more prevalent in women with parental history of MI, so we could not replicate the previous findings of the risk-increasing effect of DD genotype in this sample. Although the observed difference in the ACE DD genotype between the high-risk and low-risk areas for coronary heart disease might represent one of the genetic factors contributing to the difference in risk of coronary heart disease between eastern and southwestern Finland, the data emphasize the fact that also other risk factors, including other genes, contribute to this difference and the high incidence of MI in Finland.
血管紧张素转换酶（ACE）基因插入（I）/缺失（D）多态性的缺失/缺失基因型已被认为是心肌梗死（MI）的一个危险因素。本研究的目的是评估在芬兰基因隔离人群中，冠心病高风险和低风险地区个体之间ACE基因I/D多态性的基因型分布是否存在差异，并通过比较有不同MI家族史的个体来评估这种遗传危险因素的影响。使用了来自芬兰两个地区的具有代表性的基于人群的中年男性（n = 363）和女性（n = 358）样本。地区对DD基因型的患病率有临界显著影响（β = 0.35，标准误 = 0.16，X2 = 470，自由度 = 1，P = 0.03），DD基因型在芬兰东部（高风险地区）更为普遍。II基因型在有MI家族史的女性中更为普遍，因此我们未能在该样本中重现之前关于DD基因型增加风险效应的研究结果。尽管在冠心病高风险和低风险地区观察到的ACE DD基因型差异可能代表了导致芬兰东部和西南部冠心病风险差异的遗传因素之一，但数据强调了这样一个事实，即其他危险因素，包括其他基因，也促成了这种差异以及芬兰MI的高发病率。
