Shimokawa H, Nakaike R, Takeshita A
Research Institute of Angiocardiology, Kyushu University School of Medicine, Fukuoka, Japan.
Gerontology. 1995;41 Suppl 1:28-33. doi: 10.1159/000213718.
The significance of the defective endothelial signal transduction in the impaired endothelium-dependent relaxations in atherosclerosis and related conditions was examined. Pertussis toxin-sensitive endothelium-dependent relaxations were prominently impaired in experimental atherosclerosis in pigs. The expression of endothelial Gi protein was reduced in atherosclerosis and related conditions in human coronary arteries. Thus, the dysfunction of pertussis toxin-sensitive G protein (Gi protein) may contribute to the impairment of the endothelium-dependent relaxations in atherosclerosis.
研究了动脉粥样硬化及相关病症中内皮依赖性舒张功能受损时，内皮信号转导缺陷的意义。在猪的实验性动脉粥样硬化中，百日咳毒素敏感的内皮依赖性舒张功能明显受损。在人类冠状动脉的动脉粥样硬化及相关病症中，内皮Gi蛋白的表达降低。因此，百日咳毒素敏感的G蛋白（Gi蛋白）功能障碍可能导致动脉粥样硬化中内皮依赖性舒张功能受损。
