Adam D, Hostalek U, Tröster K
Kinderklinik, Dr. von Haunerschen Kinderspital der Universität, München, Germany.
Infection. 1995;23 Suppl 2:S83-6. doi: 10.1007/BF01742990.
In an open, controlled, randomized multicenter study, 160 children suffering from pharyngitis and/or tonsillitis were treated with either 8 mg cefixime/kg body weight once daily for 5 days or 20,000 I.U. penicillin V/kg body weight t.i.d. for 10 days. One hundred fifty-one children were evaluable for clinical efficacy. In the cefixime group, 65 (86.7%) children were cured, seven (9.3%) were significantly improved, one (1.3%) relapsed and in two (2.7%) therapy failed. Of the patients treated with penicillin V, 69 (90.8%) were cured, five (6.6%) improved, one (1.3%) relapsed and in one (1.3%) therapy failed. Elimination of initial pathogens occurred in 57 (82.6%) patients treated with cefixime and in 60 (88.2%) treated with penicillin V. At 3 to 4 weeks after the end of treatment, six relapses were seen in the cefixime group and eight in the penicillin V group. Mild-to-moderate adverse events that were possible related to the medication were seen in four children treated with cefixime and in five treated with penicillin V.
在一项开放性、对照、随机多中心研究中，160名患有咽炎和/或扁桃体炎的儿童接受了以下治疗：每日一次，8毫克头孢克肟/千克体重，持续5天；或每日三次，20,000国际单位青霉素V/千克体重，持续10天。151名儿童可评估临床疗效。在头孢克肟组中，65名（86.7%）儿童治愈，7名（9.3%）显著改善，1名（1.3%）复发，2名（2.7%）治疗失败。在接受青霉素V治疗的患者中，69名（90.8%）治愈，5名（6.6%）改善，1名（1.3%）复发，1名（1.3%）治疗失败。接受头孢克肟治疗的57名（82.6%）患者和接受青霉素V治疗的60名（88.2%）患者初始病原体被清除。治疗结束后3至4周，头孢克肟组出现6例复发，青霉素V组出现8例复发。在接受头孢克肟治疗的4名儿童和接受青霉素V治疗的5名儿童中观察到可能与药物相关的轻至中度不良事件。
