Weiss W J, Jacobus N V, Petersen P J, Testa R T
Infectious Disease Research Section, American Cyanamid Company, Pearl River, New York 10965, USA.
J Antimicrob Chemother. 1995 Jul;36(1):225-30. doi: 10.1093/jac/36.1.225.
The in-vitro activities of two glycylcyclines, DMG-MINO and DMG-DMDOT, and several comparative agents were determined against 263 enterococci, 102 methicillin-resistant Staphylococcus aureus and 55 Streptococcus pneumoniae recent clinical isolates. The glycylcyclines and teicoplanin were the most active agents against the enterococcal isolates. All methicillin-resistant S. aureus were susceptible to the glycylcyclines. Only DMG-DMDOT, ciprofloxacin, teicoplanin and vancomycin exhibited comparable activity against penicillin-susceptible, -intermediate and -resistant S. pneumoniae strains.
测定了两种甘氨酰环素（DMG-MINO和DMG-DMDOT）以及几种对照药物对263株肠球菌、102株耐甲氧西林金黄色葡萄球菌和55株肺炎链球菌近期临床分离株的体外活性。甘氨酰环素和替考拉宁是对肠球菌分离株活性最强的药物。所有耐甲氧西林金黄色葡萄球菌对甘氨酰环素均敏感。只有DMG-DMDOT、环丙沙星、替考拉宁和万古霉素对青霉素敏感、中介和耐药的肺炎链球菌菌株表现出相当的活性。
