Ariyoshi K, Berry N, Wilkins A, Ricard D, Aaby P, Nauclér A, Ngom P T, Jobe O, Jaffar S, Dias F, Tedder R S, Whittle H
Medical Research Council Laboratories, Banjul, Gambia.
J Infect Dis. 1996 Jan;173(1):245-8. doi: 10.1093/infdis/173.1.245.
A community-based study of provirus load in human immunodeficiency virus (HIV) type 2-infected subjects was done in a rural village in Guinea-Bissau. HIV-2 provirus load varied considerably, with a geometric mean of 124.3 (95% confidence interval, 86.0-179.6) copies/10(5) CD4 cells, which is a level similar to that found in HIV-1 infection. Neither malaria parasitemia, active syphilis, or human T cell leukemia virus coinfection significantly influenced provirus load, nor did age. Eleven of 104 HIV-2-infected subjects had died after 3 years of follow-up; 9 of those who died had a high provirus load of > or = 100 copies/10(5) CD4 cells and a relatively low CD4 cell percentage of < 29%.
在几内亚比绍的一个乡村开展了一项针对2型人类免疫缺陷病毒（HIV）感染受试者前病毒载量的社区研究。HIV-2前病毒载量差异很大，几何平均值为124.3（95%置信区间，86.0 - 179.6）拷贝/10⁵ CD4细胞，这一水平与在HIV-1感染中发现的水平相似。疟原虫血症、活动性梅毒或人类T细胞白血病病毒合并感染以及年龄均未对前病毒载量产生显著影响。在104名HIV-2感染受试者中，有11人在3年随访后死亡；其中9名死亡者的前病毒载量较高，≥100拷贝/10⁵ CD4细胞，且CD4细胞百分比相对较低，<29%。
