Rao S P, Taori G M, Desikan K V, Nayar S
Dept. of Preventive & Social Medicine, Shri VN Govt. Medical College, Yavatmal.
Indian J Lepr. 1995 Apr-Jun;67(2):167-76.
Fifty-three persons with tuberculoid type of leprosy having a thickened nerve on one side and a clinically normal nerve on the contralateral side were studied before, during and after two years of therapy for electrophysiological abnormalities in apparently normal and in obviously thickened nerves. Twenty-seven patients had received treatment with dapsone 100 mg orally and 26 cases had received rifampicin therapy. It was found that there was no extension of anesthesia or diminution of motor power over a period of two years. There was no significant difference between the initial and final recordings of motor and sensory nerve conductions if aggregate figures were taken. However, taking individual cases, deterioration in nerve conduction (increased latency and decreased velocity) was found in two patients, of whom one had received dapsone and the other had received rifampicin.
对53例结核样型麻风患者进行了研究，这些患者一侧神经增粗，对侧神经临床正常，在治疗前、治疗期间及治疗两年后，观察明显正常及明显增粗神经的电生理异常情况。27例患者接受了口服100mg氨苯砜治疗，26例接受了利福平治疗。结果发现，在两年时间里，麻醉范围没有扩大，运动能力也没有减弱。如果将总体数据进行汇总，运动和感觉神经传导的初始记录和最终记录之间没有显著差异。然而，就个别病例而言，发现有2例患者神经传导恶化（潜伏期延长、速度减慢），其中1例接受了氨苯砜治疗，另1例接受了利福平治疗。
