Bona M, Boudeville P, Zekri O, Christen M O, Burgot J L
UFR des Sciences Pharmaceutiques et Biologiques, Departement d'Etudes Physicochimiques et Biocinétiques des Pharmacosystèmes, Rennes, France.
J Pharm Sci. 1995 Sep;84(9):1107-12. doi: 10.1002/jps.2600840914.
Water/n-octanol partition coefficients (log P) for 33 1,2-dithiole-3-thiones and for 18 1,2-dithiol-3-ones were determined by RP-HPLC measurement of the concentration of the solute in aqueous solution after equilibrium. Depending on the nature of the substituents (alkyl or aryl) and their position(s) (4,5, or both) on the dithiole nucleus, some peculiar behaviors were revealed. Therefore, different fragmental constants containing the 1,2-dithiole-3-thione nucleus were inferred in order to calculate in a complementary work, a priori, the log P values of new dithiolethiones and dithiolones.
