Yoshikawa R, Utsunomiya J
Second Department of Surgery, Hyogo College of Medicine.
Nihon Rinsho. 1995 Nov;53(11):2734-6.
Hereditary solitary adenomas is characterized by a low number of adenomatous polyps (usually fewer than 100), but still carries an elevated risk of colon cancer. This colon cancer susceptibility disorder is believed to be inherited as an autosomal dominant. Recent molecular studies have revealed that the mutant alleles responsible for this disorder is mapped to the adenomatous polyposis coli (APC) locus on human chromosome 5q. The average age at onset for developing cancer is approximately 15 years later than that observed in classical APC and approximately 10 years earlier than patients with sporadic colorectal cancer.
遗传性孤立性腺瘤的特征是腺瘤性息肉数量较少（通常少于100个），但患结肠癌的风险仍然较高。这种结肠癌易感性疾病被认为是常染色体显性遗传。最近的分子研究表明，导致这种疾病的突变等位基因定位于人类5号染色体上的腺瘤性息肉病（APC）基因座。患癌的平均发病年龄比经典APC患者晚约15年，比散发性结直肠癌患者早约10年。
